International Review of Ophthalmology

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Research progress on new  intervention methods for dry eye and their mechanisms of protective effects on ocular surface microenvironment

CHU Chen-chen, RU Yu-sha, ZHANG Yan, HUANG Yue, ZHAO Shao-zhen.
  

  1. Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Tianjin Medical University School of Optometry and Ophthalmology, Tianjin 300384, China
  • Received:2017-06-15 Online:2017-12-22 Published:2017-12-21
  • Contact: ZHAO Shao-zhen, Email: zhaosz1997@sina.com
  • Supported by:

    National Natural Science Foundation of China Youth Fund（81600705）

Abstract:

The study of new  intervention methods on dry eye mainly focuses on maintaining the balance of ocular surface microenvironment, primarily including the following three aspects. (1)Anti-inflammation such as reducing the expression of inflammation factors and damage-associated molecular patterns(DAMPs). (2)Anti-oxidation such as maintaining the balance between oxidase and antioxidant enzymes and activing endoplasmic reticulum stress. (3)Maintaining stability of tear film by increasing the content of mucin and lipid.(Int Rev Ophthalmol,  2017,  41:   400-405)